Emerging data suggest that gastric pacing achieved by using implantable electrodes may have significant weight-loss effects. Behavioral modification for weight loss addresses learned behaviors that contribute to excessive food intake, poor dietary choices or habits, and sedentary activity habits. Serretti A, Mandelli L. The management of obesity is not complete without attention being paid to potential comorbidities. At the present, orlistat is the only medication approved by the US Food and Drug Administration FDA for use as an adjunct for weight loss in adolescents. Also crucial is a clear assessment of the patient's level of motivation regarding the changes in diet, exercise, and behavior required to maintain weight loss.
Patient Screening, Assessment, and Expectations
Studies involving humans are for the most part badly designed. A few quality studies have been carried out over the years, starting in 1998 with a double-blind, placebo-controlled trial of 135 adults over 12 weeks published in The Journal of the American Medical Association. They found no evidence that hydroxycitric acid, the active ingredient in weight loss products made from garcinia cambogia, produced significant weight loss.
The American Journal of Clinical Nutrition in 2004 published a systematic review of meta-analyses and clinical trials on dietary supplements for weight loss by complementary medicine researchers at the Universities of Exeter and Plymouth.